Tigecycline is regarded as the last line of defense to combat multidrug-resistant Klebsiella pneumoniae. However, increased use has led to increased drug resistance and treatment failures. Here we design D-alpha tocopheryl polyethylene glycol nanorods by succinate and S-thanatine peptide functionalized based on calcium phosphate nanoparticles for tigecycline delivery and treatment pneumonia caused by tigecycline-resistant pneumoniae. After incubation with bacteria, the fabricated nanorods can inhibit the accumulation of tigecycline in bacteria via the inhibitory effect of the efflux pumps exerted by polyethylene glycol tocopheryl succinate and the ability targeting S-thanatin to bacteria. The synergistic antibacterial capacity between S-thanatin and tigecycline further enhances the antibacterial activity of nanorods, thus overcoming the tigecycline resistance of Klebsiella pneumoniae.
Source: https://www.nature.com/articles/s41467-022-31500-3
Date: 29Jun,2022
