Nanoparticle-based drug delivery methods (NP) have significantly advanced the field of cancer treatment. Artificial cell membranes or cell membranes derived from nature can be incorporated into synthetic constructs or NPs using the biomimetic NP method, a new type of nanoplatform. Numerous NPs coated with cell membranes have been described in the literature using membranes from platelets and nucleated cells. According to the findings in the literature, NPs with cell membrane coatings (MEM) already actively express their self-markers, allowing them to adhere to tumor cells and sites.
Biomimetic Nanoparticles for the Treatment of Triple Negative Breast Cancer In this article, the authors discussed the development of a biomimetic NP construct with NPs coated by cell membranes that have a particular affinity for triple negative breast cancer cells.
An ectopic xenograft tumor, the MDA-MB-231 breast cancer mouse model, was used to confirm the superior anti-tumor efficacy of the neutrophil membrane-cloaked NP construct. The researchers demonstrated that the inherent membrane features of the proposed NPs, which resulted in improved circulation, self-binding capacity, and recognition/targeting capabilities of the source cells, allowed for successful targeting and tumor delivery overall. The core of PVP-TA NPs coated with activated human neutrophil membranes was present, according to the analysis of PVT-NEU NPs. The study`s findings supported PVTNEU NPs’ increased targeting and engagement with tumor cells, which enhanced a model therapeutic agent’s therapeutic activity.
Compared to PTX alone in MDA-MB-231, PTX-loaded PVT-NEU NPs demonstrated a substantial change of 2. 95-fold reduction. In conclusion, this study described the creation, improvement, and characterization of a biomimetic nanoconstruct that combined cell membrane properties and provided the NPs with a biological identity for treating breast cancer cells. In a xenograft mouse model, neutrophil membrane-coated nanoconstructs showed tumor retention, enhanced cellular targeting, and relatively less biodistribution in healthy organs.
The authors stated that this method of biomimetic-designed nanoconstructs has promise as a drug delivery system with the potential for enhanced therapeutic outcomes, active tumor targeting, and fewer adverse effects compared to traditional chemotherapy for the treatment of breast cancer. They mentioned that the results of this study could be used to inform the design of experiments for the targeted drug delivery to the tumor site for additional disease models with comparable traits.
Date: Aug 23 2022
Source: https://www.azonano.com/news.aspx?newsID=39580
